Trintellix (vortioxetine) is an antidepressant often used to treat major depressive disorder (MDD). It can be effective in treating depression, but stopping Trintellix (especially suddenly) may lead to withdrawal symptoms. Trintellix withdrawal symptoms can be distressing and confusing, particularly if you weren’t expecting them. That’s why understanding what to expect during Trintellix withdrawal can help you prepare and know when to seek support.
Next Steps
If you’re struggling with addiction, you don’t have to face it alone. At Casa Capri, we offer expert, women-centered care in a supportive and nurturing space—designed by women, for women. Our team is here to help you heal with purpose and connection.
Call our admissions team for a free, confidential chat—we’ll even check your insurance and estimate any costs upfront.
Why Withdrawal Symptoms Happen
When you take antidepressants like Trintellix, your brain gets used to the way they affect serotonin. If the medication is stopped too quickly, your brain may struggle to adjust, which can lead to Trintellix withdrawal. This type of condition is sometimes referred to as “discontinuation syndrome.” This is not a sign of addiction, but rather your body’s response to the sudden change.
Common Trintellix Withdrawal Symptoms
Withdrawal symptoms from Trintellix vary, but here are the most common signs you may encounter:
- Dizziness or lightheadedness
- Nausea or upset stomach
- Headaches
- Trouble sleeping or vivid dreams
- Irritability or mood swings
- Anxiety
- Brain zaps (a sensation like electric shocks in the head)
- Flu-like symptoms
These symptoms can appear within a few days of stopping the medication and may last for several days to a few weeks, depending on your body and the duration of your Trintellix use.
Factors That Can Affect Trintellix Withdrawal Severity
Because everyone responds differently to withdrawal symptoms of Trintellix, your experience may be different than someone else’s. That said, the following factors may increase the chance or intensity of withdrawal symptoms:
- Stopping Trintellix suddenly instead of tapering
- Taking the medication for a long time
- Using a higher dose
- Having a history of sensitivity to medication changes
- Co-occurring mental health conditions
Working with a doctor to create a safe tapering schedule can help reduce the risk of severe symptoms.
How Long Does Trintellix Withdrawal Last?
Trintellix has a relatively long half-life compared to some other antidepressants, meaning it stays in your system longer. Because of this, the Trintellix withdrawal timeline may take longer to start, but can also last longer. Most people notice symptoms within a week of stopping and feel better within two to four weeks. However, some individuals may experience longer-lasting symptoms, depending on their health and any other medications they are taking.
How to Manage Trintellix Withdrawal
The best way to manage withdrawal symptoms is to work closely with a healthcare provider. Gradually tapering off the medication can give your body time to adjust. Additional support strategies may include:
- Getting plenty of rest and hydration
- Practicing calming activities like meditation or deep breathing
- Avoiding alcohol or other drugs that may affect your mood
- Talking to a therapist or counselor during the transition
If Trintellix withdrawal symptoms become severe or significantly interfere with daily life, consult a medical professional.
When to Seek Professional Help
You should seek professional help if:
- Your withdrawal symptoms last longer than two weeks
- You experience suicidal thoughts or severe depression
- You feel physically unwell and can’t function day to day
- Your symptoms are worsening instead of improving
Casa Capri Recovery is an industry-leading women’s detox center in Orange County, California. We provide expert, women-centered support for those going through medication transitions as part of addiction or mental health treatment. You don’t have to go through this alone—our compassionate team is here to help guide you through recovery with care and respect.
Next Steps
If you’re struggling with addiction, you don’t have to face it alone. At Casa Capri, we offer expert, women-centered care in a supportive and nurturing space—designed by women, for women. Our team is here to help you heal with purpose and connection.
Call our admissions team for a free, confidential chat—we’ll even check your insurance and estimate any costs upfront.
FAQs About Trintellix Withdrawal Symptoms
Can Trintellix withdrawal be dangerous?
Most withdrawal symptoms can be uncomfortable but not life-threatening. However, some people may experience serious mood changes or suicidal thoughts. This is why it’s important to taper off Trintellix under medical supervision and seek help if your symptoms feel overwhelming.
How can I safely taper off Trintellix?
You should always speak to your doctor before stopping Trintellix. A slow, step-by-step taper over several weeks can help your body adjust and reduce the risk of withdrawal symptoms.
Is it possible to avoid Trintellix withdrawal symptoms completely?
Some people experience little to no withdrawal symptoms, especially if they taper slowly. However, others may still feel symptoms even with a gradual reduction. Every person is different.
Can I go back on Trintellix if the withdrawal is too hard?
In some cases, doctors may recommend restarting Trintellix at a low dose and tapering more slowly. You should never restart the medication on your own without medical advice.
Are there other medications that can help during Trintellix withdrawal?
Depending on your situation, your doctor may prescribe temporary medications to help with anxiety, sleep issues, or nausea. These are meant to support Trintellix withdrawal symptoms, and medically-assisted support is usually short-term.
